Pharma Analgesic Powder Drugs Diphenhydramine HCL Powder For Allergic Disease CAS 147-24-0

Synonyms:
Ethanamine,hydrochloride,Alledryl;Allergina;Amidryl;Bagodryl;Bena;Benadrilhydrochloride;Benison;Benodine;Benzantin;Denydryl;Dibondrin;Dimedrol;Diphantine;Fenylhist;
Density:1.024 g/cm3
Melting Point:168-172 °C
Boiling Point:343.7 °C at 760 mmHg
Flash Point:101.5 °C
Solubility:1000 g/L in water
Package: 1 kg in a aluminum bag
Storage: store in dry and clean environment

Diphenhydramine Hydrochloride / Diphenhydramine Hcl Description:

Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(diphenylmethoxy)-N,N -dimethylethylamine hydrochloride and has the molecular formula C17H21NO•HCI (molecular weight 291.82). It occurs as a white odorless, crystalline powder and is freely soluble in water and alcohol.

Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells.

A single oral dose of Diphenhydramine hydrochloride is quickly absorbed with maximum activity occurring in approximately one hour. The duration of activity following an average dose of Diphenhydramine hydrochloride is from four to six hours. Diphenhydramine is widely distributed throughout the body, including the CNS. Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.

Allergies:
Diphenhydramine is effective in treatment of allergies. As of 2007 it was the most commonly used antihistamine for acute allergic reactions in the emergency department.
By injection it is often used in addition to epinephrine for anaphylaxis. Its use for this purpose had not been properly studied as of 2007. Its use is only recommended once acute symptoms have improved.
Topical formulations of diphenhydramine are available, including creams, lotions, gels, and sprays. These are used to relieve itching, and have the advantage of causing fewer systemic effects (e.g., drowsiness) than oral forms.
Movement disorders
Diphenhydramine is used to treat Parkinson's disease-like extrapyramidal symptoms caused byantipsychotics.
Sleep:
Because of its sedative properties, diphenhydramine is widely used in nonprescription sleep aids for insomnia. The drug is an ingredient in several products sold as sleep aids, either alone or in combination with other ingredients such as acetaminophen (paracetamol). An example of the latter is Tylenol PM. Diphenhydramine can cause minor psychological dependence. Diphenhydramine can cause sedation and has also been used as an anxiolytic.
Nausea:
Diphenhydramine also has antiemetic properties, which make it useful in treating the nausea that occurs invertigo and motion sickness.