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| Name: | Phenacetin | CAS: | 62-44-2 |
|---|---|---|---|
| Purity: | 99% | Apperance: | White Powder |
| Package: | Discreet Ways Of Packing For Customs Pass Guaranteed | Usage: | Antipyretic Analgesic |
| High Light: | pain killer powder,local anesthetic powder |
||
99% Purity Analgesics Powder Phenacetin Acetophenetidin For Antipyretic Analgesic 62-44-2
Phenacetin Property:
Name: Phenacetine
Storage temp: 2-8°C
Color: white powder
Water Solubility: 0.076 g/100 mL
Sensitive: Hygroscopic
Merck: 14,7204
BRN: 1869238
Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
Description:
Phenacetin also called acetophenetidin. Having glossy leaflets or scales-like crystals that have no odor or taste. Melting point 134 ~ 137. Stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in
ether, soluble in ethanol, chloroform. It is formed through the etherification,reduction and Acetylation
reaction of p-chloronitrobenzene. As chloroacetanilide antipyretic and analgesic agent. Suitable for fever,
headache, neuralgia and other drugs as a compound agent.
Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,
low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic
effect. Because the enzyme inhibitor make phenacetins not be converted into paracetamol, still showed
obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The
mild phenacetisns analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid
coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic
analgesic. This product is also a component of the APC tablet.
Application:
Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetis has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treatrheumatoid arthritis (subacute type) and intercostal neuralgia.
Function:
Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,
low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic
effect. Because the enzyme inhibitor make phenacetins-Acetate not be converted into paracetamol, still showed
obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The
mild phenacetins-Acetate analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid
coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet.
COA:
Item |
Specifications | Results |
| Description | White or almost white crystalline powder | Conform |
Identity |
1,IR complies | Conform |
| 2,X-Ray complies | Conform | |
| 3,HPLC complies | Conform | |
| Optical rotation | -77.0 | -78.0 |
| Loss on drying | Not more than 0.5% | 0.32% |
Related substances |
1,Cabergolin Imp A no more than0.15% | 0.05% |
| 2,Allylamide no more than 0.10% | 0.03% | |
| 3,Allyl DHLA no more than 0.15% | 0.06% | |
| 4,Cabergoline oxide no more than 0.10% | 0.04% | |
| 5,Other impurities individually no more than 0.10% | 0.03% | |
| 6,Total no more than 0.50% | 0.21% | |
| Assay(HPLC) | 98.0%~102.0%(recalculated on anhydrous basis) | 99.4% |
Residual solvents |
1,Dichloromethane no more than 100ppm | 15ppm |
| 2,Acetone no more than 200ppm | 15ppm | |
| 3,Tert-butylmethylether no more than 200ppm | 11ppm | |
| 4,Xylene no more than 1500ppm | 135ppm | |
| 5,Heptane no more than 1000ppm | 20ppm | |
| Residue on ignition | No more than0.10% | 0.03% |
| Heavy metals | No more than 20ppm | 1ppm |
| Particle size | 90% of particles no more than 80um | Conform |
| Bulk density | 0.20~0.35g/cm3 | 0.33g/cm3 |
| Conclusion | The results conforms with EP6.0/USP30 standard. | |
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