Fat Burning Drug Lose Weight Steroids DNP Powder 2 4-Dinitrophenol CAS 51-28-5

DNP (2, 4-Dinitrophenol) Description:

2, 4-Dinitrophenol is used in the manufacture of dyes, wood preservatives, and as a pesticide. The acute (short-term) effects of 2, 4-dinitrophenol in humans through oral exposure are nausea, vomiting, sweating, dizziness, headaches, and loss of weight. Chronic (long-term) oral exposure to 2, 4-dinitrophenol in humans has resulted in the formation of cataracts and skin lesions, weight loss, and has caused effects on the bone marrow, central nervous system (CNS), and cardiovascular system. Limited or no information is available on the developmental, reproductive, or carcinogenic effects of 2, 4-dinitrophenol in humans. EPA has not classified 2, 4-dinitrophenol for carcinogenicity.

DNP (2, 4-Dinitrophenol) Applications:

DNP, its role is to make the de-coupling of oxidation and phosphorylation. Once given to 10-4M concentration of mitochondria, the uncoupling effect occurs, oxygen absorption is increased, P: O decline, if further given the high concentration will hinder the absorption of oxygen. DNP as a mechanism of action uncoupler is: DNP did not inhibit transfer of electrons, but it can eliminate the proton driving force required for the synthesis of ATP. Since DNP is a lipophilic compound is weakly acidic, it passes through the neutral state proton mitochondrial inner membrane lipid bilayer. When there is a proton gradient across the membrane, it is incorporated in the acidic side of the membrane proton to become a neutral state uncharged, by diffusion through the membrane, and in the alkaline side of the membrane to release a proton, thereby neutralized cross membrane proton gradient.

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