API Antipyretic Analgesic Indometacin Indomethacin Powder CAS 53-86-1 Anti Inflammatory

99% Purity API Antipyretic Analgesic Indometacin Indomethacin Powder CAS: 53-86-1 Anti Inflammatory

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Description:

Indomethacin is a kind of stronger corticoid anti-inflammatory and antipyretic and analgesic, by inhibiting cyclooxygenase reducing the synthesis of prostaglandin (PG), to prevent the formation of the nere impulses, inflammation tissue inhibiting inflammatory reaction, including inhibition of leukocyte chemotaxis and lysosomal enzyme release, etc., and produce antipyretic, analgesic and anti-inflammatory effects. Indomethacin anti-inflammatory, antipyretic effect is very strong, its anti-inflammatory effect is better than bute, 84 times better than hydrocortisone, and sugar cortical hormone, used in combination with aspirin, bute, can reduce their dosage, toxic and side effects, improve curative effect; Second is antipyretic effect, 10 times than amidopyrine ;its analgesic action is weak , only to the inflammatory pain has obvious analgesic effect, but the effect is good for inflammatory pain than Baotai loose, analgin and salicylic acid. Clinical is mainly used for the salicylic acid, drugs are less tolerance or curative effect is not obvious in the acute and chronic rheumatic or rheumatoid arthritis, ankylosing spondylitis, slippery bursa phlogistic, tenosynovitis, articular capsulitis, osteoarthritis and acute gout and cancerous pain, etc.In recent years, the researchers try to use indomethacin biliary colic, dysmenorrhea, migraine, glomerulonephritis, polyuria, salmonella gastroenteritis, orthostatic hypotension, bart syndrome and so on, all have good curative effect.It can also be used to treat eye pigment meningitis, keratitis, scleritis, glaucoma and fever caused by cancer or other difficult to control the fever. Dermatologist for lupus erythematosus (sle), white plug syndrome, scleroderma, nodular erythema, herpes zoster, joint type of psoriasis, etc. photosensitive dermatitis induced by topical treatment of eczema, allergic dermatitis, and local pain.

Function:
This product has obvious effect on anti-inflammation and antipyretic, can be easily absorbed and excreted. It can be fully absorbed after taken orally in the gastrointestinal tract, and in 1-4 hours the plasma concentration will reach a peak; It will be excreted by liver metabolism, with the urine. Analgesic effects on inflammatory pain there, and its mechanism of inhibiting prostaglandin synthesis. Salicylic acid is mainly used on the efficacy of drugs difficult to tolerate, or not significant rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and so on. Can also be used for acute gout and cancer, fever, or other difficult to control fever.

Indometacin--Usage and dosage
1. Anti-rheumatism: adult dosage: oral: early quantity from 25 to 50 mg each time, 2 ~ 4 times a day, immediately take at food service or after a meal. Such as good tolerance, the daily dosage can be increased from 25 to 50 mg per week, the most mount should not be more than 200 mg a day. Arthritis patients such as persistent pain at night or morning stiffness, can give quantity of 100 mg in bed all day.

2. Resistance to gout: oral: At the beginning quantity is 100 mg once, then 50 mg, three times a day, until the pain relief, and then gradually reduced as soon as possible, until the drug withdrawal.

3. Antifebrile: adult dosage: oral: 25 ~ 50 mg each time, 3 ~ 4 times daily.Rectal drug delivery: every time 50 mg, 50 to 100 mg per day. Pediatric dosage: oral: 0.5 ~ 1 mg/kg each time, 3 times a day.

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