Protein Peptide Hormones 99% Pentadecapeptide Bpc 157 White Powder Human Growth Polypeptide CAS 137525-51-0

Protein Peptide Hormones 99% Pentadecapeptide Bpc 157 White Powder Human Growth Polypeptide CAS 137525-51-0

Quick Details:

Synonyms :Bpc 15, Bpc-157, Booly protection compound 15

CAS NO. :137525-51-0

Molecular Weight :1419.53552

Molecular Formula :C62H98N16O22

Appereace:White powder

Sequence :Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

Storage :Lyophilized BPC 157 is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting BPC 157 should be refrigerated at temperatures not to exceed 36 F.

BPC 157 is known for super quick and professional Joint/tendon/ligament healing in all phases of clinical trials.. studies are shown here: BPC 157 has been shown in studies to heal torn quadriceps muscles, detached achilles tendon, muscles that have been damaged/crushed. Demonstrating dramatic fast recovery from muscle tears. Tendon to bone healing - increased ligament healing, BPC 157 has a variety of protective effects in the organs.

Description:

BPC 157 Pentadecapeptide composed of 15 amino acids, is a partial sequence of body protection compound Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Stable gastric pentadecapeptide BPC 157 may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects.

Application & Effects:

1) BPC 157's anti-inflammatory properties have LED to the theory that the peptide can be an effective ally in the battle against periodontal disease, which allow it to be an effective ally in the healing of wounds. Scientific study on rat Achillies tendons that were cut transversely (that is, transected), have demonstrated that the introduction of the peptide significantly boosted the outgrowth tendon explants

2) BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts

3) The peptide's anti-inflammatory properties theoretically allow it to be an effective ally in the healing of wounds. Scientific study on rat Achillies tendons that were cut transversely (that is, transected), have demonstrated that the introduction of the peptide significantly boosted the outgrowth tendon explants

Usage:

BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon.

This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay.

However, the survival of BPC 157-treated cells was significantly increased under the H(2)O(2) stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered.

In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.

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