Chlornitromycin/Chloramphenicol Quick Detail:
CAS Number: 56-75-7
Melting point: 48-150 °C
storage temp: 2-8°C
Einecs No: 200-287-4
Appearance: White powder
Package: 25kg/cardboard drum
Delivery time: within 12 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS,Aramex.
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Manufacturer: Zhuzhou Interial Biotechnology Co., Ltd
Lead time: Within 12 hours upon receipt of payment
Usage : Genus of broad-spectrum antibacterial antibiotics,it is the treatment of typhoid, paratyphoid medicine, one of the effective drug for the treatment of anaerobic infections, secondly for the treatment of various susceptible disease caused by microbial infections .
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes meningitis, plague, cholera, and typhoid fever. Its use is only recommended when safer antibiotics cannot be used. Monitoring both blood levels of the medication and blood cell levels every two days is recommended during treatment. It is available intravenously, by mouth, and as an eye ointment.
Common side effects include bone marrow suppression, nausea, and diarrhea. The bone marrow suppression may result in death. To reduce the risk of side effects treatment duration should be as short as possible. People with liver or kidney problems may need lower doses. In young children a condition known as gray baby syndrome may occur which results in a swollen stomach and low blood pressure. Its use near the end of pregnancy and during breastfeeding is typically not recommended. Chloramphenicol is a broad-spectrum antibiotic that typically stops bacterial growth by stopping the production of proteins.
Chloramphenicol is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.
The most serious adverse effect associated with chloramphenicol treatment is bone marrow toxicity, which may occur in two distinct forms: bone marrow suppression, which is a direct toxic effect of the drug and is usually reversible, and aplastic anemia, which is idiosyncratic (rare, unpredictable, and unrelated to dose) and generally fatal.
Because of its excellent blood-brain barrier penetration (far superior to any of the cephalosporins), chloramphenicol remains the first-choice treatment for staphylococcal brain abscesses. It is also useful in the treatment of brain abscesses due to mixed organisms or when the causative organism is not known.
Use of intravenous chloramphenicol has also been associated with gray baby syndrome, a phenomenon resulting from newborn infants' inability to metabolize chloramphenicol in the body. Other less serious reactions include fever, rashes, headache, and confusion. Prescription use is usually associated with monitoring of a patient's complete blood count. The drug should be discontinued upon appearance of reticulocytopenia, leukopenia, thrombocytopenia, anemia, or any other abnormal blood study findings attributable to chloramphenicol.
Although unpublished, recent research suggests chloramphenicol could also be applied to frogs to prevent their widespread destruction from fungal infections.It has recently been discovered to be a life-saving cure for chytridiomycosis in amphibians.
Chloramphenicol is unusual nitroaromatic metabolite produced by Streptomyces venezuelae, first published in 1947. Chloramphenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Although restricted to ocular use, antibiotic resistance to other classes has refocused attention on this class. Chloramphenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Chloramphenicol has been extensively studied with over 35,000 literature citations.