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Strong SARMS Raw Powder GW0742 / GW610742 Reduces Lung Injury CAS 317318-84-6

Good quality Protein Peptide Hormones for sales
Good quality Protein Peptide Hormones for sales
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Strong SARMS Raw Powder GW0742 / GW610742 Reduces Lung Injury CAS 317318-84-6

China Strong SARMS Raw Powder GW0742 / GW610742 Reduces Lung Injury CAS 317318-84-6 supplier
Strong SARMS Raw Powder GW0742 / GW610742 Reduces Lung Injury CAS 317318-84-6 supplier Strong SARMS Raw Powder GW0742 / GW610742 Reduces Lung Injury CAS 317318-84-6 supplier

Large Image :  Strong SARMS Raw Powder GW0742 / GW610742 Reduces Lung Injury CAS 317318-84-6

Product Details:

Place of Origin: Hunan,China
Brand Name: Muscle Man
Certification: GMP, HSE, ISO 9001, USP, BP
Model Number: CAS: 317318-84-6

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: Discreet Ways Of Packing For Customs Pass Guaranteed
Delivery Time: Within 12 Hours Upon Receipt Of Payment
Payment Terms: Western Union, Money Gram, Bitcoin, Paypal, T/T
Supply Ability: 500-1000kg Per Month
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Detailed Product Description
Purity: 99% Payment Terms: Western Union, Money Gram , T/T, Bitcoin
Certification: SGS, ISO 9001, KOSHER Origin: China
MF: C₂₁H₁₇F₄NO₃S₂ MW: 471.49
Appearance: White Powder The Solvent / Solubility: DMSO: ≥ 34 Mg/mL

Raw Strong Bulking Sarms Powder GW0742 CAS 317318-84-6 GW610742 PPAR Agonist Reduces Lung Injury​

 

GW0742 / GW610742 Quick Detail:

CAS Number. 317318-84-6
chemical name GW0742/GW610742
Synonyms GW0742;GW 0742X;GW 610742;GWdelta 0742;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]AceticAcid;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID;4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid;Acetic acid, 2-[4-[[[2-[3-fluoro-4-(trifluoroMethyl)phenyl]-4-Methyl-5-thiazolyl]Methyl]thio]-2-Methylphenoxy]-
CBNumber: CB4138491
MF C21H17F4NO3S2
MW 471.49
Melting Point 134.5-135.5 °C
Storage Temperature 2-8°C
Solubility DMSO: >5 mg/mL

 

GW0742 / GW610742 Description:

GW0742, also known as GW610742, is a PPARδ/β agonist. GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons. GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. GW0742 has direct protective effects on right heart hypertrophy.GW0742 may enhance lipid metabolism in heart both in vivo and in vitro.

 

GW0742 / GW610742 Biological Activity:

GW0742 / GW610742 is a potent and highly selective PPARδ agonist. EC50 values are 1nM, 1.1μM and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively.
GW0742 is a synthetic high affinity PPAR β/δ agonist, and its possible role in preventing the advance of inflammatory and apoptotic processes induced by bleomycin, that long-term leads to the appearance of pulmonary fibrosis. Our data showed that GW0742-treatment (0.3 mg/Kg, 10 percent DMSO, i.p.) has therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters detected by measurement of:cytokine production;  leukocyte accumulation, indirectly measured as decrease of myeloperoxidase (MPO) activity; IkBα degradation and NF-kB nuclear translocation; ERK phosphorylation; stress oxidative by NO formation due to iNOS expression; nitrotyrosine and PAR localization; the degree of apoptosis, evaluated by Bax and Bcl-2 balance, FAS ligand expression and TUNEL staining. Taken together, our results clearly show that GW0742 reduces the lung injury and inflammation due to the intratracheal BLEO--instillation in mice.

Strong SARMS Raw Powder GW0742 / GW610742 Reduces Lung Injury CAS 317318-84-6

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