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AMP Activated Protein Kinase Activator Aicar AMPK For Lymphoblastic Leukemia Treatment

Good quality Protein Peptide Hormones for sales
Good quality Protein Peptide Hormones for sales
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AMP Activated Protein Kinase Activator Aicar AMPK For Lymphoblastic Leukemia Treatment

China AMP Activated Protein Kinase Activator Aicar AMPK For Lymphoblastic Leukemia Treatment supplier
AMP Activated Protein Kinase Activator Aicar AMPK For Lymphoblastic Leukemia Treatment supplier AMP Activated Protein Kinase Activator Aicar AMPK For Lymphoblastic Leukemia Treatment supplier AMP Activated Protein Kinase Activator Aicar AMPK For Lymphoblastic Leukemia Treatment supplier

Large Image :  AMP Activated Protein Kinase Activator Aicar AMPK For Lymphoblastic Leukemia Treatment

Product Details:

Place of Origin: Hunan,China
Brand Name: Muscle Man
Certification: GMP, HSE, ISO 9001, USP, BP
Model Number: CAS: 2627-69-2

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: Discreet Ways Of Packing For Customs Pass Guaranteed
Delivery Time: Within 12 Hours Upon Receipt Of Payment
Payment Terms: Western Union, Money Gram, Bitcoin, Paypal, T/T
Supply Ability: 500-1000kg Per Month
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Detailed Product Description
Express Way: EMS, FedEx, TNT, DHL, Hkems Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
Assay: 98% Appearance: White Or Off-white Powder
Packing: Discreet Ways Of Packing For Customs Pass Guaranteed Specification: GMP, USP, ISO9001

Quick Detail:

Alias: AICAR;AICA-RIBOSIDE;AMPK;Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Assay: 98%
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Molecular Structure:
AMP Activated Protein Kinase Activator Aicar AMPK For Lymphoblastic Leukemia Treatment
Melting Point: 214-215 °C
Storage Instructions:Store at -20°C (desiccating conditions).
Solubility Overview:Soluble in water to 50 mM and in DMSO to 100 mM (with heating)
Properties: white or off-white powder.
Usage: pharmaceutical intermediates.For the treatment of cardiovascular diseases.

AMP Activated Protein Kinase Activator Aicar AMPK For Lymphoblastic Leukemia Treatment

Description:

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFKB and C/EBP pathways.

 

Specification:

Item Specification Result
Appearance White powder Complies
Related substance (HPLC) Total impurity ≤0.5%
Max single impurity ≤0.1%
0.2%
0.06%
Odor Characteristic Complies
Assay 99% 99.8%
Sieve analysis 100% pass 80 mesh Complies
Loss on Drying
Residue on Ignition
≤1.0%
≤1.0%
0.12%
0.09%
Heavy Metal <10ppm Complies
As <0.1ppm 0.05ppm
Pb <0.1ppm 0.05ppm
Cd <0.1ppm 0.05ppm
Residual Solvents <100ppm Complies
Residual Pesticide Negative Complies
Microbiology    
Total Plate Count <1000cfu/g Complies
Yeast & Mold <100cfu/g Complies
E.Coli Negative Complies
Salmonella Negative Complies

 

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