Payment & Shipping Terms:
|EINECS::||227-226-4||Packing:||Discreet Package To Pass The Customs.|
|Payment:||Western Union, Money Gram, Bitcoin, Paypal, T/T||Purity:||>99%|
|Shipping Method:||Hkems, DHL, FedEx .UPS, TNT||Delivery Time:||Within 12 Hours Upon Receipt Of Payment|
|Molecular Formula:||C29H46O3||Molecular Weight:||442.68|
99.9% Purity Anti-allergic Agents Powder Fluocinolone Acetonide 356-12-7 for Anti-Inflammatory
|Characteristics||White crystalline powder|
|Effective Dose (Men)||300-2000 mg/week|
|Packaging||Discreet package to pass the customs.|
|Delivery Time||Within 12 hours after receiving the payment.|
|Standard||SGS; GMP; ISO9001|
|Min order||10 grams|
Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibioticneomycin.
|Fluocinolone acetonide Usage And Synthesis|
|Corticosteroid drug||Fluocinolone acetonide is a kind of topical corticosteroids of the most significant effect and the least side effect in current china, and can cause the contraction of dermal capillary, inhibit cell proliferation or regeneration of connective tissue; it can also stabilize the intracellular lysosomal membrane and prevent the release of histamine from the intracellular lysosomal enzyme and the further tissue damage. The anti-inflammatory effects of Fluocinolone is 100 times as great s that of hydrocortisone. It has significant efficacy even at the lowest concentration (0.025%) with rapid onset rate and can significantly reduce or cure the symptoms in a few days with a relative excellent itching relief effect. Fluocinolone acetonide is mainly used for the treatment of skin diseases to which glucocorticoid is effective such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, neurodermatitis, dermatitis, eczema (especially infant eczema), pruritus disease, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa and so on. Its combination with neomycin and other antibiotics can be used for the treatment of suppurative skin disease. Apply 0.025-0.05% ointment, lotion for scrubbing the affected area with 2-3 times per day. You can gently knead and make it be incorporated into the skin.|
|Physical and Chemical Properties||It appears as white or white-like crystalline powder and is odorless and tasteless. [α] D20+80-+88° (dioxane). It is soluble in acetone, slightly soluble in ethanol, dioxane but insoluble in water and petroleum ether. It is obtained through the sulfonic esterfication, ring-opening reaction and further 16-steps reactions starting from the 11α-hydroxy-16α, 17α-epoxy pregnane-4-ene-3, 20-dione. It can be applied to atopic dermatitis, contact dermatitis, eczema and other skin diseases.|
|Fluocinolone acetonide||Fluocinolone acetonide is a synthetic, fluorine-containing potent steroid. Topical administration of it can cause dermal capillary contraction and can inhibit epidermal cell proliferation or regeneration, inhibit the newborn of the fibroblast cells inside the connective tissue and stabilize the intracellular lysosomal membrane with anti-inflammatory and anti-itching effect. After topical administration, it can be absorbed through intact skin. After its absorption, similar as the metabolism of corticosteroid after systemic administration, it is mainly metabolized in the liver and can be excreted by the kidneys. Fluocinolone acetonide is suitable for treating the skin disease to which corticosteroid is effective skin such as eczema (especially eczema), neurodermatitis, skin pruritus, contact dermatitis, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa, and solar dermatitis. However, it should be note that long-term or large-scale application can cause skin atrophy, telangiectasia and the occurrence of acne-like dermatitis, perioral dermatitis, folliculitis, and increased susceptibility to infection and so on. Allergic contact dermatitis can also occur in some cases.
This information is edited by Xiongfeng Dai from Chemicalbook.
|Uses||It is suitable in the treatment of eczema, neurodermatitis, skin pruritus, contact dermatitis, psoriasis, dermatitis and other diseases|
|Chemical Properties||Crystalline Solid|
|Uses||A synthetic glucocorticoid VEGF inhibitor.|
|Definition||ChEBI: A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatme t of various skin disorders.|
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