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|Package:||Discreet Ways Of Packing For Customs Pass Guaranteed||MF:||C21H18F3NO3S2|
SARMS Raw Powder GW 501516 Fat Burning Sarms Powder Cardarine Gw-501516 /GSK-516
GW 501516 Specification
|Alias:||Alias:2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid; GW1516; GW501516; GSK-516|
|Usage||Fat loss,Endurance&recovery increase|
|Minimum Order Quantity:||5g|
|Payment Terms:||Western Union, MoneyGram, T/T, Bank Transfer;Bitcoin|
|Lead Time:||Within 12 hours after receiving the payment|
|Delivery||By DHL, TNT, FedEx, HKEMS, UPS, etc.|
|Packaging Details:(Normal)||1kg/aluminium foil bag or as required|
|Supply Ability:||Mass in stock|
What is GW-501516:
GW501516 (GW1516 or GSK-516) is a drug that acts as a PPARd modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions, especially when used in conjunction with a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in animal studies. GW-501516 regulates fat burning through a number of widespread mechanisms; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization. This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity.
How it works:
GW501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ.
In rats, binding of GW501516 to PPARδ recruits the co activator PGC-1a. The PPARδ/coactivator complex in turn up regulates the expression of proteins involved in energy expenditure. Furthermore in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1.
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SARMs Supplying List:
|Selective Androgen Receptor Modulators Supplying List|
|Product Name||CAS Number||Product Name||CAS Number|
|Ostarine, MK-2866,||841205-47-8; 1202044-20-9||GW-501516||317318-70-0|